Blacklegged ticks pose the highest risk to humans in New England due to their ability to transmit multiple pathogens. Nymphal ticks are particularly dangerous because their small size makes them difficult to detect. American dog ticks, while less risky, can transmit Rocky Mountain Spotted Fever and Tularemia, though these cases are rare in the region. Lone star ticks are associated with alpha-gal syndrome, which can cause allergic reactions to red meat, as well as Ehrlichiosis and Tularemia. Longhorned ticks, though primarily a threat to livestock and pets, can occasionally bite humans. The spread of these ticks underscores the need for vigilance, especially in wooded and grassy areas.